It's not impossible to do but it's highly dangerous. your tolerance will build your brain chemistry will alter greatly your immune system will bottom out....I am serious when I say I can relate but the fact is this might be ok for a year or less but then the negative effects that start to appear are almost always for the rest of your like. Sure you use supplement s to try to low effects but in the end it's just m9ore torture. Just my opinion, I'm no a biotechnologist but I try to research as much as possible in my free time. X) nomad